Ankylosing spondylitis, Klinikai vizsgálatok a Ankylosing Spondylitis
What does the test show?
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The assay can be used to determine the presence of the HLA-B27 gene. This gene predisposes to the development of certain joint autoimmune diseases.
Many joint diseases are caused by a malfunction of the ankylosing spondylitis system. In such cases, the immune system identifies each cell in the joints as infected and attacks them in response.
Immune cells, when they get into the joint cells, cause permanent inflammation. HLA-B27, a specific protein that can be detected on the surface of white blood cells, helps identify foreign substances for the immune system.
In which cases is it recommended to perform the test? However, the test is not specific and clearly does not diagnose any disease.
The diagnosis can only be made with an accurate knowledge of the symptoms and with other laboratory tests. It is usually prescribed at the same time as other tests for chronic arthritis, joint pain, the presence of joint stiffness, and suspected autoimmune disease.
What sample is needed for the test? A blood sample taken from a vein is needed to perform the test.
Modified Schober's Test for Ankylosing Spondylitis
What can the result indicate? The test result determines the presence of the HLA-B27 gene, however, there is no clear diagnosis of any of the affected autoimmune diseases.
In which cases is it recommended to perform the test?
If the test is negative, the gene is not found in the body. However, this does not mean that the autoimmune diseases mentioned above do not develop in the individual, as patients do not always carry the gene.
Both diseases have been associated with generalized and localized bone loss, accelerated atherosclerosis, increased CV morbidity and mortality. Bone and vascular biomarkers and parameters along with the effect of one-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Data on the effects of vascular markers on bone and bone effects on vasculature had undergone statistical analysis. Results: We found a great number of correlations between vascular and bone surrogate markers.
What to do after the test? In all cases, consult the rheumatologist who ordered ankylosing spondylitis test with the results, as the finding is not of diagnostic value in itself.
The diagnosis can only be made in the knowledge of the symptoms, and at the same time as other laboratory and imaging diagnostic tests.